Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk

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Apolipoproteins E and CIII interact to regulate HDL metabolism and coronary heart disease risk.

BACKGROUND Subspecies of HDL contain apolipoprotein E (apoE) and/or apoCIII. Both proteins have properties that could affect HDL metabolism. The relation between HDL metabolism and risk of coronary heart disease (CHD) is not well understood. METHODS Eighteen participants were given a bolus infusion of [D3]L-leucine to label endogenous proteins on HDL. HDL was separated into subspecies contain...

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Review of serum lipids and apolipoproteins in risk-assessment of coronary heart disease.

Coronary heart disease (CHD), the leading cause of death in the western world, is multifactorial in nature. Abnormal lipoprotein levels are among the risk factors that cause atherosclerosis and, therefore, have been used as biochemical markers in assessing risk of developing CHD. The measurement of serum cholesterol, lipoprotein cholesterol, and apolipoproteins accurately and reliably has been ...

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ژورنال

عنوان ژورنال: JCI Insight

سال: 2018

ISSN: 2379-3708

DOI: 10.1172/jci.insight.98045